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I was diagosed with inoperable NSCLC in March 11. I am taking Iressa as a first line treatment. I had no side effects for 2 weeks then the rash on my face started. I am female so was able to cover this with makeup. My skin became very dry too but moisturizers helped. I had tummy cramps which started at the same time, no diarrhea initially as I was still taking morphine from unsuccessful surgery. After 6 weeks I had my first scan. My tumor that had been 11cms was now 8.5cms, this was a pleasant surprise as I was told the Iressa would not shrink it but just stop it from growing. Since stopping the morphine I now suffer from tummy cramps and diarrhea most days, usually at night. I feel it is a small price to pay. I take Imodium which helps.
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Because it's the number one cancer killer.

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P12 antigen overexpression is associated with a wide range of cancer cell lines and tissues and antibody directed towards these antigens may serve as important contributors to cancer therapeutics as exemplified by the results of priliminary trials.

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Iressa in spite of the fact that test showed that the cells were negative for Iressa.

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Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non small cell lung cancer.

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Get emergency medical help if you have signs of an allergic reaction to Iressa: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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She survived thirteen years, then the cancer struck back and went to her lungs and she died.

Poor metabolizers have higher than expected plasma concentrations of TCAs when given usual doses.

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To investigate the antitumor effects and toxicity of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor gefitinib (Iressa) in advanced non-small cell lung cancer (NSCLC).

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This test should be performed in a histopathology laboratory.

It sounds like this may well be multifocal BAC, but one that is growing so incredibly slowly that there is arguably a greater risk from overtreatment than from undertreatment.

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Hyperfractionated accelerated radiotherapy (HART) in stage IIIA and IIIB patients has been evaluated by a phase II ECOG study.

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The trial is for children whose chemotherapy is no longer working and for those who have finished treatment and their neuroblastoma has come back.

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Carbon dioxide laser for early-stage disease.

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If you are taking chemotherapy tablets at home, you may notice very little change to your everyday life.

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Indeed, a substantial body of data supports the use of erlotinib in NSCLC regardless of EGFR or KRAS mutation status.

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We found that short (2-h) exposure to gefitinib had no effect on radiation response in clonogenic assays, and strictly additive interaction was observed ( and ) after 72-h contact with gefitinib.

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Dysgeusia (taste change) occurred in 12% of the patients and is different from the usual lack of taste or metallic taste that are generally associated with other medications.

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It is likely to be effective (especially for a still very small lesion), have few adverse effects than surgery, and it is more likely to preserve surrounding lung tissue that often ends up being very needed if BAC recurs in a multifocal form in the future and thereby limits functional lung.

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These precuations are based on the risk in CYP2D6 poor metabolizer patients (who are at risk of increased exposure to the drug leading to adverse events), and the EPAR states that there is a lower need for precautions in patients who are CYP2D6 extensive metabolizers.

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Several large trials have shown that local control of the tumor is significantly improved when 5FU and mitomycin chemotherapy are used with radiation, as compared to radiation alone.

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Patients undergoing some weeks of treatment usually experience fatigue caused by the healthy tissue repairing itself and aside from this there can be no side effects at all.

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If the cancer is localized to the anus and pelvic lymph nodes, it may be used in combination with radiation therapy to achieve the best chance of killing all of the cancer cells (see "Combined Modality (Chemoradiotherapy).

So based on that and a couple of phase II studies the FDA did fast track this drug and it was made available, deservedly so, to patients throughout the country.

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It seems they found a way to reduce toxic effects of chemotherapy on healthy cells so they are able to use much higher doses of cancer killing drugs than can be used in regular chemo.

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The objective of chemoimmunotherapy is to amplify natural pre-existing T cell responses specific for any known or unknown tumor antigen and to recruit and amplify new tumor-specific T cell responses resulting from the use of cytotoxic drugs.

The therascreen EGFR RGQ PCR Kit was approved as a companion diagnostic test to identify patients with tumors having the EGFR gene mutations in order to determine which patients would be appropriate for treatment with Iressa.

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