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In a similar proportion of patients receiving capecitabine or fluorouracil plus leucovorin, the dose required reduction (42 percent and 44 percent, respectively).

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To make the dendritic cell present a tumor-specific antigen, the cells can be coincubated with dead tumor cells, tumor cell fragments, tumor proteins, tumor DNA or RNA, or bacteria and viruses that have been engineered to contain tumor antigens.

But for women who started having periods at an early age and had no children, the rates were 5 percent and 10 percent, respectively, the researchers found.

Early testing with this drug, using total body weight to determine dose, revealed high levels of reversible ocular toxicity that was associated with high early exposure levels of mirvetuximab soravtansine.

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